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了解患者的经验,为未来的研究提供信息,以优化早期乳腺癌治疗的个性化
Stuart A McIntosh1, Mhairi Mactier2, Katherine Fairhurst3
1Patrick G. Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK.
Annals of surgical oncology
|May 21, 2024
概括
大多数乳腺癌患者 (82.6%) 如果安全,会省略化疗或内分泌疗法等治疗,优先考虑生活质量. 需要证据来支持个性化乳腺癌治疗决策.
科学领域:
- 在瘤学瘤学.
- 患者报告的结果
- 临床试验设计 临床试验设计
背景情况:
- 乳腺癌的治疗是多式的,患者的好处不同,严重的疾病影响生活质量.
- 人们越来越关注量身定制治疗以优化结果和减少负担,专注于患者的影响.
- 这项研究旨在探索患者的经验,以指导未来的乳腺癌研究.
研究的目的:
- 探索患者对乳腺癌治疗的看法.
- 要了解患者愿意在被认为是安全的情况下省略治疗.
- 为未来临床试验的设计提供信息,专注于治疗个性化.
主要方法:
- 使用了与患者倡导者共同开发的在线调查.
- 调查包括人口统计,接受的治疗,以及对不接受治疗的看法.
- 用描述性统计数据和自由文本主题分析分析了回复.
主要成果:
- 在235名参与者中,有82.6%的参与者会在安全的情况下放弃治疗.
- 化学疗法 (35.6%) 和内分泌疗法 (31.4%) 是最常被选为因副作用而遗漏的疗法.
- 较少的参与者会省略手术 (20.6%) 或放射治疗 (10.3%).
结论:
- 患者希望个性化优化乳腺癌治疗.
- 需要一组患者共同设计的研究组合来建立个性化证据.
- 建议优先研究减少可避免的化疗和内分泌疗法.
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