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Updated: Jun 25, 2025

3D Organotypic Co-culture Model Supporting Medullary Thymic Epithelial Cell Proliferation, Differentiation and Promiscuous Gene Expression
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福克索3调节皮质和骨髓胸膜上皮质细胞恒常,对T细胞发育有影响

Camila Ribeiro1,2,3, Pedro Ferreirinha1,2, Jonathan J M Landry4

  • 1i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.

Cell death & disease
|May 21, 2024
PubMed
概括

转录因子Foxo3对于胸膜上皮细胞 (TEC) 功能至关重要,影响T细胞发育和中央耐受性. 删除Foxo3会破坏TEC,导致T细胞种群变化和潜在的自身免疫问题.

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