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Updated: Jun 25, 2025

Cycloheximide Chase Analysis of Protein Degradation in Saccharomyces cerevisiae
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在ERAD功能障碍时,ER-to-lysosome相关的降解起到安全机制的作用

Elisa Fasana1, Ilaria Fregno1, Carmela Galli1

  • 1Faculty of Biomedical Sciences, Institute for Research in Biomedicine, Università della Svizzera italiana (USI), 6500, Bellinzona, Switzerland.

EMBO reports
|May 21, 2024
PubMed
概括

当阻断内质网膜相关降解 (ERAD) 时,细胞会激活ER-lysosome相关降解 (ERLAD) 途径. 这种由FAM134B驱动的过程清除了错误折叠的蛋白质,确保了细胞蛋白质稳定.

关键词:
与ER相关的退化 (ERAD)这是ER-phagy.随着ER-to-lysosome相关的退化 (ERLAD) 的发生.细胞内膜网膜 (ER) 是一个蛋白质质量控制 蛋白质质量控制

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