通过将孟德尔的抽样差异考虑在两代前的情况,通过配对信息来改进选择决策
Tobias A M Niehoff1, Jan Ten Napel2, Piter Bijma2
1Animal Breeding and Genomics, Wageningen University and Research, Droevendaalsesteeg 1, 6700AH, Wageningen, The Netherlands. Tobias.niehoff@wur.nl.
Genetics, selection, evolution : GSE
|May 21, 2024
概括
一个新的选择标准,ExpBVSelGrOff,通过考虑未来的后代,加速育种计划中的遗传收益. 这种方法增强了遗传进步,并保持了遗传变异,而不会增加近亲繁殖率.
科学领域:
- 动物育种与遗传学
- 量化遗传学 量化遗传学
- 基因组选择 基因组选择
背景情况:
- 繁殖计划的目的是通过选择精英动物来最大限度地提高遗传进步.
- 繁殖值的个体差异和游戏变异 (由于异卵性和结合) 影响后代的表现.
- 之前的方法,如实用性标准 (Index5),考虑了游戏性门德尔采样变异.
研究的目的:
- 开发和评估一个新的选择标准,ExpBVSelGrOff,该选择计划一代人前进.
- 评估将潜在后代的游戏门德尔抽样变异纳入选择标准的影响.
- 将ExpBVSelGrOff与现有标准进行比较,以确定其在加速遗传收益和维持遗传变异方面的有效性.
主要方法:
- 提出了一个新的选择标准,ExpBVSelGrOff,结合了个体及其潜在后代的游戏门德尔抽样变异.
- 在21代的繁殖计划中进行了随机模拟.
- 将ExpBVSelGrOff与既定标准 (例如,实用性标准,Index5) 进行比较,使用遗传收益,遗传变异和近亲繁殖率等指标.
主要成果:
- 在模拟中,ExpBVSelGrOff的表现超过了所有测试标准.
- 在经过五代强选择 (1%) 后,ExpBVSelGrOff实现了5.8%的更大遗传收益,并保留了25%的更多遗传变异.
- 新的标准保持了基因变异,而不会影响内生繁殖率.
结论:
- ExpBVSelGrOff提供了一个新的工具,可以加速基因组育种计划中的遗传进步.
- 与短期规划方法相比,该标准实际上保留了更多的遗传变异.
- 纳入未来的游戏门德尔采样变异是一种有前途的策略,可以在育种计划中保存遗传变异.
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