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在患有双相情感障碍的女性患者中,异常葡萄糖脂,生殖激素和认知功能障碍之间的关联
Tianxiang Zou1, Min Yang1, Zhuohui Chen2
1Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China.
BMC psychiatry
|May 21, 2024
概括
女性的双极性障碍 (BD) 与认知缺陷和改变的葡萄脂代谢和生殖激素有关. 这些荷尔蒙和代谢变化可能会导致BD女性患者的认知障碍.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 双极性障碍 (BD) 与失调的葡萄糖脂代谢和生殖激素有关.
- 这些代谢和荷尔蒙异常在患有BD的女性中尤其令人担忧.
研究的目的:
- 为了研究女性BD患者的葡萄脂和生殖激素水平.
- 探索这些水平与女性BD患者认知功能之间的关系.
主要方法:
- 招募了58名未服用药物的女性BD患者,61名稳定服用药物的女性BD患者和63名健康对照.
- 测量了血清糖脂指数和生殖激素.
- 使用可重复电池评估神经心理状态 (RBANS) 和Stroop颜色-词试验评估认知功能.
主要成果:
- 无论药物状态如何,BD患者都表现出显著的认知障碍.
- 稳定药物治疗的BD患者表现出甘油三 (TG),黄素激素 (LH) 和高密度脂蛋白胆固醇 (HDL-c) 的水平发生变化.
- 孕激素 (PRGE) 和益生菌 (PRL) 与稳定药物治疗的BD患者的认知表现有负面关联.
结论:
- 女性BD患者可能会出现认知缺陷,以及异常的葡萄糖脂和生殖激素水平.
- 这些荷尔蒙和代谢变化可能与这一群体的认知功能障碍有关.
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