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莫格罗斯V降低了过度的内等质网膜应激,并减轻了小鼠中酸硫酸诱导的性结肠炎

Yue-Rong Tan¹, Si-Yang Shen¹, Xin-Yi Li¹

¹College of Veterinary Medicine, Jilin University, No. 5333 Xi'an Road, Changchun, Jilin, 130062, China.

Journal of translational medicine

|May 22, 2024

概括

摩格洛西德V (MV) 通过通过内分泌网膜应激 (ERS) 途径减少炎症和亡,有效地治疗小鼠的性结肠炎 (UC). 这种僧侣水果化合物为UC患者提供了潜在的新疗法.

科学领域:

胃肠病学胃肠病学
分子生物学分子生物学
药理学药理学是指药理学的学科.

背景情况:

性结肠炎 (UC) 是一种慢性炎症性结肠疾病,治疗选择有限.
细胞内膜网膜应激 (ERS) 通过亡促进了UC病变的发生.
来自果的Mogroside V (MV) 具有抗炎和抗氧化特性.

研究的目的:

为了研究MV在硫酸 (DSS) 诱导的UC中的治疗潜力.
阐明MV作用的基本机制,重点关注ERS-亡途径.

主要方法:

在小鼠中使用DSS诱导UC.
用MV给UC诱导的小鼠.
评估疾病活动,结肠长度,组织学和炎症标志物.
对ERS和与亡相关的蛋白质表达的分析.
评估MV与突尼卡米辛 (Tm) 的疗效,这是一个ERS激活剂.

主要成果:

MV治疗降低了UC的严重程度,由较低的DAI得分和改善的结肠组织学表明.
MV降低了促炎性细胞因子和肠道透性.
MV抑制了ERS标记物 (BIP,PERK,eIF2α,ATF4,CHOP) 和亡蛋白 (Caspase-12,Bax/Bcl-2比率) 的表达.
图尼卡米辛治疗减少了MV的保护作用,证实了ERS通路的参与.

结论:

在小鼠中,MV显示了对DSS诱导的UC的显著治疗效果.
MV通过抑制ERS-亡途径起作用,表明其作为一种新型UC治疗的潜力.

关键词:

细胞灭亡 (apoptosis) 是一种死亡的过程.细胞内膜网膜应激压力莫格罗赛德V 类型性结肠炎是一种

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