甘油三糖指数及其相关参数与脆弱性相关联
Huangyi Yin1, Liuqing Guo1, Wei Zhu1
1The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Lipids in health and disease
|May 22, 2024
概括
较高的甘油三糖指数 (TyG) 和相关指标与成年人较高的脆弱性患病率有关. 管理血糖,脂质和肥胖可能有助于减少虚弱的风险.
科学领域:
- 老年医学 老年医学
- 代谢健康 代谢健康
- 公共卫生 公共卫生
背景情况:
- 虚弱是一种显著的老年综合征,具有动态进展.
- 有限的研究已经探索了甘油三糖 (TyG) 指数及其相关指标 (TyG-WHtR,TyG-WC,TyG-BMI) 与脆弱性之间的关联.
- 这些代谢标志物与脆弱性之间的相互关系仍然不清楚.
研究的目的:
- 调查甘油三糖 (TyG) 指数及其相关指数与脆弱性的关联.
- 使用NHANES数据分析TyG指数变化和脆弱性患病率之间的潜在联系.
主要方法:
- 利用了2003-2018年国家健康和营养检查调查 (NHANES) 的7965名参与者的数据.
- 采用二进制物流回归,受限立方线 (RCS) 和接收器运行特征 (ROC) 曲线分析.
- 进行了分层分析和相互作用测试,以探索潜在的混因素.
主要成果:
- 在参与者中,脆弱性患病率为25.59%,平均脆弱性指数为0.16.
- 泰格指数及其相关指数 (TyG-WC,TyG-WHtR,TyG-BMI) 在回归模型中显示出与脆弱性有显著的积极关联.
- 与其他指数相比,TyG-WHtR显示了虚弱的最高诊断值 (AUC:0.654).
结论:
- 提升的TyG指数及其相关指标与脆弱性患病率的增加有关.
- 控制血糖和脂质,以及预防肥胖,可能对减轻中年和老年人的脆弱性至关重要.
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