在乳腺癌手术中用利多卡因注射预防持续性疼痛 (PLAN):多中心随机对照试验的研究协议
James S Khan1, Ian Gilron2, P J Devereaux3
1Department of Anesthesiology & Pain Medicine, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada. james.khan@medportal.ca.
Trials
|May 22, 2024
概括
术后静脉输注利多卡因可以预防乳腺癌手术后的持续性疼痛. 这项研究调查了其在减少乳房切除术后疼痛综合征 (PMPS) 和改善幸存者的生活质量方面的有效性.
科学领域:
- 在瘤学瘤学.
- 麻醉学 麻醉学
- 疼痛管理 疼痛管理
背景情况:
- 持续性疼痛或乳腺切除术后疼痛综合征 (PMPS) 是乳腺癌手术后的一种严重并发症.
- 越来越多的乳腺癌幸存者强调需要有效的疼痛预防策略.
- 在外科手术期间,静脉注射利多卡因正在作为PMPS的潜在预防性干预措施进行研究.
研究的目的:
- 为了最终评估手术内静脉注射利多卡因输注对预防乳腺癌手术后持续疼痛的影响.
- 评估利多卡因对减少乳房切除术后疼痛综合征 (PMPS) 的发生率和严重性的影响.
主要方法:
- 一个多中心,随机,安慰剂对照试验,涉及1602名接受乳腺癌手术 (乳腺切除或乳腺切除) 的患者.
- 参与者在手术期间接受了静脉注射利多卡因玻尿酸和输液或安慰剂 (正常盐水).
- 测量的主要结果是手术后3个月内持续疼痛的发生率.
主要成果:
- 这项研究旨在提供关于利多卡因在预防术后持续性乳腺癌疼痛方面的有效性的明确证据.
- 二次结果包括疼痛发病率,阿片类药物消费和不同时间点的功能参数.
- 此外,还将进行成本效益分析.
结论:
- 成功的结果可能会导致将利多卡因输注纳入标准乳腺癌护理.
- 这种干预提供了一种潜在的廉价和可访问的方法,以减少乳腺癌幸存者的疼痛和痛苦.
- 该研究旨在降低慢性疼痛管理成本,并可能减少阿片类药物使用,从而改善患者的生活质量.
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