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一个网络对不可切割的头部和部状细胞癌中系统疗法的元分析

Jinling Yuan¹, Kexin Shi¹, Guanhua Chen²

¹The First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, China.

Cancer control : journal of the Moffitt Cancer Center

|May 22, 2024

概括

同时的化疗和放射治疗是头癌的标准. 将其与诱导化疗或向治疗相结合可能会改善结果,尽管目前没有一种治疗方法显著超过标准护理.

科学领域:

在瘤学瘤学.
辐射疗法辐射疗法
医学瘤学医学瘤学

背景情况:

头部局部发达状细胞癌 (LASCCHN) 通常用并发化疗放射治疗 (CRT) 治疗.
临床试验中正在研究新的治疗策略,以改善患者的治疗结果.

研究的目的:

用贝叶斯网络元分析来比较不可切除的LASCCHN的所有可用的治疗方法.
提供对整体存活 (OS) 和无进展存活 (PFS) 治疗有效性的直接和间接比较.

主要方法:

对2000年1月至2023年7月期间发表的随机对照试验 (RCT) 进行了系统审查.
关于OS和PFS的数据是从选定的RCT中提取的.
用随机效应进行贝叶斯网络元分析来合成证据.

主要成果:

对OS和PFS的治疗排名是使用积累排名 (SUCRA) 下面表面值生成的.
分析包括各种诱导化疗 (IC),放射治疗 (RT) 和强度调节放射治疗 (IMRT) 的组合.
没有一种治疗策略在标准并发化学放射治疗 (CRT) 上显示出具有统计学意义的优势.

结论:

同时化学放射治疗仍然是LASCCHN.的既定标准治疗方法.
将CRT与诱导化疗或向治疗相结合显示出改善患者治疗结果的潜力.
进一步的研究可能会阐明LASCCHN.的最佳治疗顺序和组合.

关键词:

拉斯科恩 (LASCCHN) 是一个化学疗法化疗化疗网络元分析网络元分析辐射疗法辐射疗法

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