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量化宿主对致命病原体的耐药性和耐受性的物种内变异

Bennett M Hardy^1,2,3, Erin Muths⁴, W Chris Funk^1,3

¹Graduate Degree Program in Ecology, Colorado State University, Fort Collins, Colorado, USA.

The Journal of animal ecology

|May 22, 2024

概括

与科罗拉多州的种群相比,怀俄明州的北方对致命的两真菌Batrachochytrium dendrobatidis (Bd) 具有更高的耐受性和耐药性. 内部变异对于理解人口减少和为保护工作提供信息至关重要.

科学领域:

生态生态学生态生态学
保护生物学保护生物学
病原体-宿主动态病原体-宿主动态

背景情况:

由于真菌病原体Batrachochytrium dendrobatidis (Bd) 的两动物数量下降是一个重要的保护问题.
科罗拉多州的北极 (Anaxyrus boreas boreas) 已经从Bd中经历了严重的下降,而怀俄明州的种群似乎受到影响较小.
宿主耐受性和耐药性的特定变异可以影响人口层面的疾病结果.

研究的目的:

调查野生北极种群中对Batrachochytrium dendrobatidis (Bd) 的耐受性和耐药性的内属变异.
确定耐受性和耐药性的差异是否解释了Bd诱导的人口下降的区域差异.
评估多状态建模方法对理解动态感染过程的有用性.

主要方法:

一个常见的花园感染实验是使用四个种群 (两个在科罗拉多州,两个在怀俄明州) 的变形后北方进行的.
青暴露于Batrachochytrium dendrobatidis (Bd),并在八周内监测质量变化,病原体负担和生存时间.
使用多州建模方法来估计感染和清除状态之间的每周生存和过渡概率.

主要成果:

怀俄明州的北方对Bd感染的耐受性显著更高,与科罗拉多州的相比,在相同的病原体负载下生存概率增加.
怀俄明州的青也表现出更大的耐药性,更高的清除感染的概率和更长的时间来达到峰值的病原体负担.
在被研究的种群之间观察到耐受性和耐药性的强烈内部特异性差异.

结论:

对Batrachochytrium dendrobatidis的耐受性和耐药性的特定变异在解释北极的差异性种群下降方面发挥着关键作用.
保护策略,包括养殖和转移,应该考虑这种物种内特异性变异.
多状态建模框架在评估宿主耐受性和耐药性时,为隐藏的疾病动态提供了有价值的见解.

关键词:

巴特拉科希特 (Batrachochytrium dendrobatidis) 是一种类型的植物.两动物的数量正在减少.主体的抵抗力宿主的抵抗力主体的耐受性宿主的耐受性种内特定变化的变化.多个国家多个国家.

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