综合耐力和抵抗运动减轻了与年龄相关的心脏功能障碍
Xiaowei Han1, Muhammad Ashraf1, Hong Shi2
1Department of Pharmaceutical Sciences, USF Health Taneja College of Pharmacy, University of South Florida, Tampa, FL, USA.
Advanced biology
|May 22, 2024
概括
综合运动,包括耐力和抵抗训练,通过激活上游刺激因子2 (Usf2) 来改善老年小鼠的心脏功能. 这种干预可以缓解心脏衰老和功能障碍,建议Usf2作为治疗点.
科学领域:
- 心脏病学 心脏病学
- 老年学是指老年学的学科.
- 分子生物学分子生物学
背景情况:
- 老龄化导致心脏功能下降和心血管疾病风险增加.
- 运动是减轻心血管风险的一种已知的策略.
- 结合耐力和抵抗运动对心脏衰老的具体益处尚未完全理解.
研究的目的:
- 为了研究耐力和阻力运动对老年小鼠心脏功能的影响.
- 为了确定在生命晚期运动诱导心脏保护的基础上的分子机制.
- 探索上游刺激因子2 (Usf2) 在缓解与年龄有关的心脏功能障碍中的作用.
主要方法:
- 年龄较大的小鼠 (22个月大) 接受了联合炼计划 (游泳和抵抗跑步).
- 对心脏组织进行了转录组分析.
- 评估了心脏功能,病理性缩,氧化应激和衰老.
- 使用人类心肌细胞的体外研究调查了Usf2.2的作用.
主要成果:
- 在老年小鼠中,联合运动训练改善了心脏功能,并减轻了与年龄相关的病态心脏缩,氧化应激和衰老.
- 转录组分析显示,与心肌收缩,线粒和寿命调节相关的途径被激活.
- 上游刺激因子2 (Usf2) 在对运动的反应中被上调.
- 过度表达Usf2在人类心肌细胞中表现出抗衰老作用,而敲击则加剧了衰老.
结论:
- 综合耐力和阻力运动有效地对抗与年龄有关的心脏重塑和生命晚期功能障碍.
- 心脏保护作用与Usf2的激活及其抗衰老特性有关.
- Usf2为与年龄有关的心脏功能障碍提供了一个潜在的新疗法标.
更多相关视频
相关概念视频
Exercise and Cardiovascular Response
787
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
787
Exercise and Muscle Performance
1.4K
Exercise induces a range of adaptations in muscle tissue, depending on the type and duration of activity. Such physical training can be broadly categorized into two types: endurance exercises and resistance exercises.
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
1.4K
Exercise and Cardiac Output
991
Regular physical activity is essential for maintaining cardiovascular health, with aerobic exercises being particularly effective. According to the American Heart Association, 150 minutes of moderate to intense aerobic exercise per week is recommended for a healthy heart. Aerobic activities may include brisk walking, running, bicycling, cross-country skiing, and swimming, ideally performed three to five times per week.
Sustained exercise increases the muscles' oxygen demand, which can be...
Sustained exercise increases the muscles' oxygen demand, which can be...
991
Imbalances in Cardiac Output
1.4K
The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
1.4K
Pathophysiology of Cardiac Performance
638
Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...
638
Pathophysiology of Heart Failure
1.6K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.6K


