人工智能电心电图可以预测慢性淋巴细胞白血病患者的心房动
Georgios Christopoulos1, Zachi I Attia1, Sara J Achenbach2
1Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA.
JACC. CardioOncology
|May 22, 2024
概括
人工智能心电图 (AI-ECG) 在慢性淋巴细胞白血病 (CLL) 患者中有效预测心房动 (AF) 风险. 将AI-ECG与Mayo CLL AF风险评分相结合,可以提高新诊断个体的预测准确度.
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 人工智能的人工智能
背景情况:
- 人工智能心电图 (AI-ECG) 算法可靠地预测一般人群中心房动 (AF) 风险.
- 慢性淋巴细胞白血病 (CLL) 与心血管并发症风险增加有关,包括AF.
研究的目的:
- 评估AI-ECG评分在识别高风险发展AF的CLL患者中的有效性.
- 为了比较AI-ECG的预测性能与建立的梅奥诊所CLL AF风险评分.
主要方法:
- 从梅奥诊所的CLL数据库中估计了754名新诊断的CLL患者的AI-ECG得分.
- 梅奥诊所CLL AF风险评分被计算出来,并确定其预测AF的能力.
- 用布鲁顿氨酸激酶抑制剂治疗的220名CLL患者的二次队列被分析了治疗前AI-ECG风险.
主要成果:
- 基线AI-ECG得分≥0.1表明新诊断的CLL患者的AF风险显著增加 (HR:3.9;P<0.001).
- 这种增加的AF风险在调整其他临床因素后仍然显著 (HR:2.5;P<0.001).
- 在接受布鲁顿氨酸激酶抑制剂治疗的CLL患者中,治疗前AI-ECG得分≥0.1显示了非显著的AF风险增加 (HR:1.7;P = 0.19).
结论:
- AI-ECG与梅奥CLL AF风险评分一起,可以预测新诊断的CLL患者的AF风险.
- 需要进行进一步的研究,以确定AI-ECG对在接受布鲁顿氨酸激酶抑制剂治疗的CLL患者中AF风险预测的有用性.
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