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超快速利斯普罗改善食后血糖控制与利斯普罗与基础胰岛素结合:一项基于CGM的研究在中国的2型糖尿病患者中
1Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Frontiers in endocrinology
|May 22, 2024
概括
超快速利斯普罗胰岛素 (URLi) 在患有2型糖尿病的中国成年人中,与利斯普罗胰岛素相比,在早餐后更好地控制了食后葡萄糖排放. 这两种胰岛素对HbA1c,低血糖和体重增加都有类似的影响.
科学领域:
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 2型糖尿病 (T2D) 的管理需要有效的血糖控制.
- 玻尿酸胰岛素在食后葡萄糖调节中起着至关重要的作用.
- 超快速利斯普罗胰岛素 (URLi) 在餐时间胰岛素治疗中提供了潜在的进步.
研究的目的:
- 为了比较URLi与胰岛素lispro的疗效和安全性,作为中国T2D患者的玻尿酸胰岛素.
- 通过使用持续血糖监测 (CGM) 来评估食后血糖控制.
- 评估血糖控制 (HbA1c),低血糖发生率和体重变化.
主要方法:
- 这是一项双盲,随机,并行,前性,第三阶段的研究.
- 57名未经控制的T2D的成年人接受了基础胰岛素治疗方案和URLi或胰岛素lispro作为玻尿酸胰岛素.
- 在基线和终点3天的CGM分析食后葡萄糖外流 (PPGE) 和其他血糖参数.
主要成果:
- 与胰岛素lispro相比,URLi显著减少了早餐后的食后葡萄糖外流 (1.59对 2.51 mmol/L,p=0.046).
- 用URLi.观察到1小时和2小时后食用葡萄糖的较大降低.
- 平均HbA1c降低,低血糖发生率和体重增加在各组之间是相似的.
结论:
- 在患有T2D的中国成年人中,URLi比胰岛素利斯普罗能更好地控制早餐后的食用葡萄糖.
- 在改善HbA1c水平方面,URLi与胰岛素lispro无差.
- 在低血糖和体重增加方面,URLi表现出类似的安全性.
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