胆固醇纳米骨基因组用于阿伦德罗纳特的向输送,作为一种抗内皮功能障碍剂
Horacio Emanuel Jerez1, Yamila Roxana Simioni1, Kajal Ghosal2
1Nanomedicine Research and Development Centre (NARD), Science and Technology Department, National University of Quilmes, Roque Sáenz Peña 352, Bernal, Buenos Aires, Argentina.
Beilstein journal of nanotechnology
|May 22, 2024
概括
通过纳米古体输送的乙烯酸盐 (ALN) 显著增强了人类内皮细胞中的抗炎作用. 这种有针对性的交付放大了ALN的ALN.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
- 血管生物学 血管生物学
背景情况:
- 乙烯酸盐 (ALN) 是一种水溶性,透性较差的抗吸收和抗化剂.
- 血管内皮的炎症是各种心血管疾病的关键因素.
- 向的纳米纤维可能会提高药物输送和疗效.
研究的目的:
- 评估ALN载荷纳米古体 (nanoARC-Chol(ALN)) 对人类静脉内皮细胞 (HUVECs) 的抗炎作用.
- 评估纳米ARC-Chol (ALN) 在不同炎症条件下降低HUVEC炎症标志物的有效性.
- 为了比较纳米ARC-Chol ((ALN) 与自由ALN和德克萨米他的治疗潜力.
主要方法:
- 纳米古体 (纳米ARC-Chol) 配制的是极性脂质和胆固醇,装载着ALN.
- 细胞毒性,线粒体膜潜力,ATP含量和HUVECs的膜流动性在纳米ARC-Chol (ALN) 内细胞化后进行了评估.
- 在轻度和明显的模型中,使用脂聚糖 (LPS) 诱导了HUVEC的炎症.
- 测量了Interleukin-6 (IL-6) 和Interleukin-8 (IL-8) 的水平,以量化抗炎反应.
主要成果:
- 用ALN装载的纳米古体 (nanoARC-Chol(ALN)) 已经成功地准备了高的ALN封装效率.
- 通过HUVECs进行的纳米ARC-Chol ((ALN) 的内细胞分解显示了内皮-介质酶过渡的部分减少.
- 在轻度 (75%和65%) 和明显 (60%和40%) 炎症模型中,nanoARC-Chol (ALN) 显著降低了IL-6和IL-8水平.
- 与纳米ARC-Chol (((ALN)) 相比,自由ALN和德克萨米他的疗效有限.
结论:
- 纳米archaeosome封装放大了HUVECs中的aendronate的抗炎活性.
- 在减少炎症标志物方面,纳米ARC-Chol (ALN) 显示出比自由ALN和德克萨米他更高的疗效.
- 这种基于纳米纤维的输送系统对治疗血管炎症充满希望.
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