传统剂量和高剂量罗库在剖腹产术全身麻醉中使用的比较
Boo-Young Hwang1,2, Dowon Lee1,2, Saeromi Chung3
1Department of Anesthesia and Pain Medicine, Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea.
International journal of medical sciences
|May 22, 2024
概括
在剖腹产期间使用更高剂量的罗库 (1.0 mg/kg) 并没有对母亲或胎儿产生负面影响,在Apgar分数或PACU停留时间上没有差异. 这表明更高的剂量对于剖腹产是安全的.
科学领域:
- 麻醉学 麻醉学
- 产科麻醉 产科麻醉 产科麻醉
- 药理学 药理学是指药理学的学科.
背景情况:
- 在剖腹产中,有限的研究使用直接度测量来比较高剂量与低剂量的罗库.
- 研究罗库的母体和胎儿血液度以及临床影响对于优化产科麻醉至关重要.
研究的目的:
- 在剖腹产期间,以高剂量 (1.0毫克/公斤) 和低剂量 (0.6毫克/公斤) 进行对比母胎血度.
- 评估这些rocuronium剂量对孕产妇和胎儿的临床影响.
主要方法:
- 18名患者被随机分为两个组:低剂量 (0.6毫克/公斤) 和高剂量 (1.0毫克/公斤) 罗库.
- 主要结局:带静脉中的罗库度.
- 二级结局:输内管的容易,神经肌肉阻断的持续时间 (TOF),PACU停留,雷米芬坦尼尔剂量,母亲的罗库水平和Apgar分数.
主要成果:
- 在人口统计学,输管易度,PACU停留或1分钟Apgar分数方面没有显著差异.
- 在高剂量组中,在带静脉和母体循环中发现了更高的罗库度.
- 高剂量组显示T3消失的时间更短,T1/T2重新出现的时间更长,需要更低的雷米芬坦尼尔.
结论:
- 罗库的1.0mg/kg剂量没有延长PACU停留时间,也没有影响剖腹产患者的Apgar分数.
- 在剖腹产期间,更高的rocuronium剂量似乎对母亲和胎儿都是安全的,有可能减少阿片类药物的使用.
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