在口腔癌中通过PI3K/AKT信号通路调解自 - - 综合性综述
Peramaiyan Rajendran1,2, Ramya Sekar3,2, Prabhu Shankar Dhayasankar4
1Department of Biological Sciences, College of Science, King Faisal University, Al-Ahsa, 31982, Saudi Arabia.
International journal of medical sciences
|May 22, 2024
概括
本综述探讨了PI3K/AKT/mTOR通路的使用情况.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 细胞信号传输 细胞信号传输
背景情况:
- 口腔癌表现出显著的临床和组织学异质性.
- 在口腔癌中,PI3K/AKT/mTOR通路经常失调,控制着细胞的重要功能.
- 针对这种途径为开发具有减少毒性的特定口腔癌疗法提供了潜力.
研究的目的:
- 为了阐明PI3K/AKT/mTOR途径在口腔状细胞癌 (OSCC) 中的调节.
- 详细介绍该途径在OSCC进展和转移期间调节自和亡中的作用.
- 确定PI3K/AKT/mTOR信号传导的上游激活剂和下游作用因子,作为口腔癌的治疗标.
主要方法:
- 文献综述侧重于口腔癌中的PI3K/AKT/mTOR信号传递.
- 对研究途径调节,自和亡的研究进行分析.
- 在PI3K/AKT/mTOR途径中识别潜在的治疗点.
主要成果:
- PI3K/AKT/mTOR通路是口腔癌中细胞和代谢活动的关键调节者.
- 这种途径的失调会影响自和亡,导致OSCC的进展和转移.
- 该途径中的特定蛋白质为新型口腔癌药物开发提供了可行的点.
结论:
- PI3K/AKT/mTOR通路是口腔状细胞癌的一个关键决定因素.
- 了解其调节机制和下游影响对于有效的口腔癌治疗策略至关重要.
- 针对PI3K/AKT/mTOR通路的组件有望改善口腔癌治疗.
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