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胰岛素低剂量治疗或不治疗的链毒素诱导的糖尿病大鼠下尿路功能障碍的时间依赖性进展

Nailong Cao^1,2, Rong Lv¹, Daisuke Gotoh²

¹Department of Urology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

International journal of medical sciences

|May 22, 2024

概括

糖尿病会导致时间依赖的下尿路功能障碍 (LUTD),膀和尿道发生变化. 低剂量胰岛素治疗可以预防这些糖尿病引起的并发症.

科学领域:

泌尿器科泌尿器科泌尿器科泌尿器科
内分泌学在内分泌学.
病理生理学病理生理学

背景情况:

糖尿病 (DM) 与下泌尿道功能障碍 (LUTD) 有关.
由于DM而导致的下泌尿道的时间依赖的功能和结构变化尚未完全理解.
研究胰岛素治疗在DM诱导的LUTD中的保护作用至关重要.

研究的目的:

为了检查链毒素诱导的糖尿病大鼠下尿路的时间依赖的功能和结构变化.
探索低剂量胰岛素治疗DM诱导的LUTD的病理生理特征.
了解DM持续时间对膀和尿道功能和结构的影响.

主要方法:

带有或没有胰岛素治疗的链毒素诱导的糖尿病大鼠模型.
评估排泄行为,体内泌尿动力学 (囊管仪表,尿道 perfusion 压力) 和体内器官浴室研究.
膀和尿道组织的组织形态学分析,使用血素-氨酸和马森染色.

主要成果:

糖尿病老鼠表现出改变的排尿模式和受损的膀光滑肌肉收缩性.
在糖尿病老鼠中,尿道光滑肌的收缩性增加,而膀光滑肌的厚度随着时间的推移而增加.
与未经治疗的糖尿病大鼠相比,胰岛素治疗减轻了排泄行为,尿动力学和组织收缩性的变化.

结论:

由DM诱导的LUTD涉及时间依赖的膀和尿道重塑,包括detrusor缩和尿道放松受损.
低剂量胰岛素治疗通过保护膀和尿道功能,显示出对DM诱导的LUTD的保护作用.
这些发现凸显了胰岛素治疗在管理DM相关下游泌尿道并发症进展方面的潜力.

关键词:

糖尿病是一种糖尿病.胰岛素是一种胰岛素.下尿道功能障碍下尿道功能障碍

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