CCCTC结合因子抑制α-2-宏球蛋白转录以改善下肢动脉样硬化 obliterans 的血管内皮细胞功能

Tianmin He1, Mengqiang You2,3, Huixin Zhu4,5

  • 1Department of Vascular Surgery, the First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, P.R. China.

概括

CCCTC-结合因子 (CTCF) 通过抑制α-2-巨型球蛋白 (A2M) 来保护下肢动脉样硬化 (LEASO) 中的血管内皮细胞. 这一发现为LEASO提供了一个新的治疗目标.

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