在小鼠视觉皮层中,刺激特异性增强需要GABA,但不需要从VIP内部神经元释放VIP
Megumi Kaneko1, Mahmood S Hoseini1, James A Waschek2
1Department of Physiology and Kavli Institute For Fundamental Neuroscience, University of California San Francisco, San Francisco, California, United States.
Journal of neurophysiology
|May 22, 2024
概括
运动通过血管活性肠 (VIP) 内神经元增强视觉皮层对特定刺激的反应. 在成年小鼠中,GABA释放,而不是VIP,对于这种刺激特异增强 (SSE) 至关重要.
科学领域:
- 神经科学是一个神经科学.
- 神经生理学 神经生理学
- 皮层可塑性 皮层可塑性
背景情况:
- 运动会在视觉皮层 (V1) 中诱导高增益状态 (V1).
- 血管活性肠 (VIP) 内神经元,释放GABA和VIP,介导运动对V1.1的影响.
- 从这些内部神经元中释放GABA和VIP的独特作用在可塑性方面仍然不清楚.
研究的目的:
- 为了阐明从VIP内部神经元释放的GABA或VIP是否负责成人视觉皮层中的刺激特异增强 (SSE).
主要方法:
- 基因剥离技术被用来选择性地去除VIP或损害成人小鼠的VIP细胞中的GABA释放.
- 刺激特异性增强 (SSE) 是通过测量V1神经元响应在运动期间重复暴露视觉刺激后进行评估的.
主要成果:
- 当小鼠在移动过程中接触到视觉刺激时,观察到SSE.
- 删除VIP并没有影响SSE.
- 从VIP细胞中破坏GABA释放可以防止SSE.
- 这些发现表明,SSE是由VIP内部神经元释放GABA介导的.
结论:
- 来自VIP内部神经元的GABA释放,而不是VIP,对于成人视觉皮层的刺激特异增强至关重要.
- 这表明,Hebbian机制可能是成年V1.0中SSE的基础.
- 这项研究挑战了关于神经在可塑性中的传统观点,强调了GABA在这种情况下的快速作用.
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