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口腔微生物群和结直肠癌之间的关系:系统性审查

Sara Camañes-Gonzalvo¹, José María Montiel-Company¹, Miriam Lobo-de-Mena²

¹Department of Stomatology, Faculty of Medicine and Dentistry, University of Valencia, Valencia, Spain.

Journal of periodontal research

|May 22, 2024

概括

口腔细菌的组成在结直肠癌患者和健康人群之间有所不同. 像Streptococcus anginosus这样的特定细菌与癌症有关,而其他细菌可能会提供保护.

科学领域:

微生物学微生物学
在瘤学瘤学.
胃肠病学胃肠病学

背景情况:

结肠直肠癌 (CRC) 是一个重要的全球健康问题.
新出现的证据表明,口腔微生物群和CRC发展之间存在联系.
了解这种关联对于早期检测和预防策略至关重要.

研究的目的:

系统地审查和综合有关口腔微生物群组成和结直肠癌之间的关联的现有证据.
为了确定特定的口腔细菌物种或属,与健康对照人群相比,在CRC患者中异常丰富.
评估目前的证据水平,并确定口腔失生症和致癌的未来研究的差距.

主要方法:

在四个主要数据库中进行了系统的文献搜索,截至2024年4月.
研究的选择是基于预定义的PECO问题,该问题是关于CRC患者与健康个体的口腔微生物差异.
研究质量使用纽卡斯尔-太华尺度进行评估,证据水平使用GRADE工具进行评估.

主要成果:

16项研究符合资格标准,提供低到中等水平的证据.
特定口腔细菌的水平升高,包括Streptococcus anginosus,Peptostreptococcus stomatis,Streptococcus物种,Prevotella intermedia,Fusobacterium nucleatum和Neisseria oralis,都与CRC有关.
某些细菌,如Lachnospiraceae,F. periodonticum和P. melaninogenica,可能对抗CRC发展具有保护作用.

结论:

在患有结直肠癌和没有结直肠癌的个体之间,口腔微生物群组成存在显著差异.
低到中等的证据支持特定的口腔细菌和CRC之间的联系.
需要进一步的研究,以阐明口腔失生症在结直肠癌发生的机制.

关键词:

结肠直肠癌是什么意思口腔中的微生物群.口腔微生物口腔微生物口腔病原体的口腔病原体牙周病原体牙周病原体

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