脑癌的非侵入性治疗使用一种独特的全身传递方法与癌症终结器病毒
Praveen Bhoopathi1,2, Padmanabhan Mannangatti1,2, Anjan K Pradhan1,2
1Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, Virginia, USA.
Journal of cellular physiology
|May 22, 2024
概括
带有微泡的聚焦超声波安全地打开了血脑屏障,使得针对脑瘤的癌症终结病毒 (CTV) 的向输送成为可能. 这种非侵入性方法提高了质母细胞瘤模型的生存率,即使使用标准疗法.
科学领域:
- 瘤治疗性病毒疗法
- 纳米医学是一种纳米医学.
- 神经外科 神经外科
背景情况:
- 原发性,质母细胞瘤和二次性脑瘤是具有攻击性和耐治疗性的.
- 血脑屏障 (BBB) 限制了对脑癌的有效治疗.
- 一种癌症终结病毒 (CTV) 为癌症选择性复制和细胞因子生产 (MDA-7/IL-24) 开发.
研究的目的:
- 为了克服BBB限制,系统性病毒传递到脑瘤.
- 评估聚焦超声波与双微气泡 (FUS-DMB) 方法用于CTV传递的有效性.
- 评估FUS-DMB介导的CTV传递在脑癌模型中的治疗潜力.
主要方法:
- 开发了一种具有Ad5囊和血清型3纤维旋的癌症终结病毒 (CTV).
- 使用聚焦超声波与双微气泡 (FUS-DMB) 处理暂时打开BBB.
- 在BBB打开后,通过补充剂处理的微泡进行CTV,然后进行聚焦超声波.
- 在动物模型中评估FUS-DMB介导的CTV传递和治疗疗效.与质母细胞瘤.
主要成果:
- 使用FUS-DMB方法证明了BBB的安全和暂时打开.
- 在动物模型中成功将CTV传递到大脑,提高了生存率.
- 多次FUS-DMB治疗进一步改善了质母细胞瘤模型中的生存率.
- 结合FUS-DMB/CTV治疗与Temozolomide产生了增加的生存益处.
结论:
- FUS-DMB方法使得在整个BBB中进行非侵入性,有针对性的CTV,用于脑癌治疗.
- 这一策略可以提高质母细胞瘤模型的存活率,没有显著的有毒副作用.
- 通过FUS-DMB介导的CTV传递代表了对初级和二级脑瘤的有希望的翻译治疗策略.
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