患有围产期艾滋病毒的儿童对4CMenB疫苗表现出明显的免疫反应
Nicola Cotugno1,2, Alessia Neri1,3, Marco Sanna1
1Clinical and Research Unit of Clinical Immunology and Vaccinology, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
JCI insight
|May 22, 2024
概括
与健康儿童相比,患有围产期获得的艾滋病毒 (PHIV) 的儿童对脑膜炎球菌疫苗的免疫反应降低. 需要进一步的研究,以了解这种脆弱人群的长期疫苗免疫力.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 儿科 儿科 儿科
背景情况:
- 患有围产期艾滋病毒 (PHIV) 的儿童表现出不理想的免疫反应,需要量身定制的疫苗接种策略.
- 乙组脑膜炎球菌 (4CMB) 疫苗对于预防侵入性脑膜炎球菌疾病至关重要.
研究的目的:
- 在接受抗逆转录病毒治疗的PHIV儿童中评估四组B组脑膜炎球菌疫苗的安全性和免疫性.
- 为了比较患有PHIV的儿童和健康对照组 (HCs) 之间的免疫反应.
主要方法:
- 向患有PHIV和HC的儿童注射两剂4CMB疫苗.
- 使用人血清杀菌抗体 (hSBA) 测定和IgG标位评估抗体反应.
- 通过流式细胞计和实时PCR研究B细胞种群和基因表达.
主要成果:
- 这种疫苗在两组中都显示出良好的安全性.
- 与HCs相比,患有PHIV的儿童显示免疫原性降低.
- 接种疫苗后,PHIV组表现出改变的B细胞子集分布和独特的基因表达模式.
结论:
- 虽然PHIV儿童的4CMB疫苗接种是安全和免疫的,但他们的免疫反应不如HC儿童那么强大.
- 接种疫苗后,PHIV与独特的免疫特征有关,影响B细胞子集.
- 在PHIV中长期的疫苗诱导免疫维持需要进一步的研究.
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