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抑制BET会改变免疫微环境,并缓解慢性淋巴细胞白血病中T细胞功能障碍

Audrey L Smith1, Sydney A Skupa1, Alexandria P Eiken1

  • 1Eppley Institute for Research in Cancer and Allied Diseases.

JCI insight
|May 22, 2024
PubMed
概括

使用 OPN-51107 阻断原蛋白和外端蛋白 (BET) 会使慢性淋巴细胞白血病 (CLL) 中的耗尽的 T 细胞恢复生命. 这种方法减少了免疫抑制,并增强了TME的抗瘤免疫力.

关键词:
药物治疗是药物治疗.免疫学 免疫学 免疫学白血病 (Leukemias) 是一种癌症.在瘤学瘤学.在T细胞,T细胞.

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