食道基线阻抗与喉回流和治疗反应相关
Christopher M Kurylo1, Jacob Noel1, Joel H Blumin1
1Department of Otolaryngology & Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin, U.S.A.
距离食道平均夜间基线阻抗 (MNBI) 可以帮助诊断喉回流 (LPR) 并预测治疗反应. 较低的MNBI值与LPR相关,并表明酸反流治疗的结果更好.
科学领域:
- 胃肠病学 胃肠病学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 医学诊断 医学诊断 医学诊断
背景情况:
- 喉回流 (LPR) 提出了诊断方面的挑战.
- 食道粘膜的完整性对于逆流管理至关重要.
- 多通道内阻抗-pH (MII-pH) 测试是一个关键的诊断工具.
研究的目的:
- 评估远隔食道平均夜间基线阻抗 (MNBI) 对LPR的诊断效用.
- 为了确定MNBI是否预测了对酸性反流治疗的症状反应.
- 将MNBI的预测能力与其他MII-pH参数进行比较.
主要方法:
- 对173名疑似LPR患者进行MII-pH测试的回顾性分析.
- 计算和评估远端食道MNBI值.
- 在118名患者中,MNBI与LPR诊断和治疗反应的关联分析.
主要成果:
- 与对照组 (2158 ± 173.5 Ω) 相比,LPR患者表现出明显较低的远端食道MNBI (1332 ± 94.8 Ω).
- 远端食道MNBI切线<1580 Ω独立预测了抗逆流疗法的积极反应 (OR = 4.148).
- 比其他MII-pH数据,MNBI被证明是治疗反应的优越预测指标.
结论:
- 远端食道MNBI是诊断LPR的一个有价值的标志物.
- 在LPR患者中,MNBI可以预测LPR患者的药物反应.
- 这种阻抗参数为LPR管理提供了一个有前途的方法.
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