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Updated: Jun 25, 2025

Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence
10:09

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由CDK12无活化诱导的MYC信号导致对拼接酶SRPK1的依赖

Jing Liang1, Aishwarya Gondane1, Harri M Itkonen1

  • 1Department of Biochemistry and Developmental Biology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

Molecular oncology
|May 22, 2024
PubMed
概括

前列腺癌中CDK12的损失驱动MYC活动,从而产生对SRPK1.1的依赖. 药物Endovion针对CDK12失活的癌细胞中的这种脆弱性.

关键词:
这就是SLAM-seqq.循环林依赖性激酶12的作用.前列腺癌是前列腺癌.拼接 拼接 拼接 拼接合成杀伤性 合成杀伤性

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