在患有高血压的患者中,早晨血压变化和大脑微型血液负担之间的关系
Dongsen Zhang1, Hongying Ma1, Chunqin Liu1
1Department of Neurology, Tangshan GongRen Hospital, Tangshan, China.
Journal of clinical hypertension (Greenwich, Conn.)
|May 22, 2024
概括
在高血压患者中,较高的早晨血压变化,特别是腹压变化,与大脑微型血流 (CMB) 的较大负担有关. 这一发现凸显了BP变异性作为高血压相关器官损伤的关键因素.
科学领域:
- 神经学 神经学
- 心脏病学 心脏病学
- 高血压研究 高血压研究
背景情况:
- 大脑微型血流 (CMB) 是高血压患者中目标器官损伤的重要形式.
- 了解CMB负担与血压 (BP) 变化之间的关系对于管理高血压并发症至关重要.
研究的目的:
- 在高血压患者中,研究大脑微型血液 (CMB) 数量与早晨血压 (BP) 变化之间的关联.
- 为了区分CMB负荷对整体和非叶片CMB的影响,关于BP变化.
主要方法:
- 招募了791名高血压患者,根据CMB计数 (1-10vs>10) 分类.
- 收集关于高血压持续时间,等级,药物和控制的数据.
- 在一个月内,每3天监测一次家庭早晨的血压测量,使用标准偏差 (SD) 和变化系数 (CV) 分析变化.
主要成果:
- 较高的早晨家庭透析血压变化 (SD和CV) 与更高的CMB负担 (>10个CMB) 有显著的关联.
- 与1-10个非叶膜CMB患者相比,患有10个非叶膜CMB的患者表现出明显更高的早晨缩和腹血压变化 (SD,CV,平均真实变化).
- 多变量分析证实,上升的早晨家庭透析血压变化 (SD,CV) 与10多个非叶膜CMB相关.
结论:
- 上升的早晨透析血压变化是增加CMB负担的显著预测因素,包括非叶片微型血液.
- 早晨的血压变化,特别是腹压变化,应被认为是评估高血压相关脑损伤的关键因素.
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