卵巢上皮癌风险的种族和种族差异:来自卵巢癌协会联盟的分析
Nicola S Meagher, Kami K White, Lynne R Wilkens
1Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, United States.
American journal of epidemiology
|May 22, 2024
概括
卵巢上皮癌 (EOC) 的危险因素在种族和族群之间有很大差异. 口服避孕药的使用和平价显示出保护作用,在亚洲和原住民夏威夷/太平洋岛屿妇女中最强.
科学领域:
- 妇科瘤学 妇科瘤学
- 流行病学 流行病学
- 癌症危险因素 癌症危险因素
背景情况:
- 有限的数据存在于各种人群中的上皮卵巢癌 (EOC) 风险因素,包括亚洲,西班牙裔和原住民夏威夷/太平洋岛屿妇女.
- 了解这些变化对于制定有针对性的预防策略至关重要.
研究的目的:
- 调查已知的EOC风险因素与不同种族和族群的EOC风险之间的关联.
- 识别风险因素关联中的潜在差异.
主要方法:
- 在卵巢癌协会联盟 (Ovarian Cancer Association Consortium) 内的11项研究数据的分析.
- 包括1734名亚洲人,266名夏威夷原住民/太平洋岛民,1149名西班牙裔和24189名白人参与者 (病例和对照).
- 逻辑回归模型用于估计因差率 (OR) 和95%置信区间 (CI) 的风险关联,根据种族和种族.
主要成果:
- 在使用口服避孕药 (OC),平价,输卵管绑定和吸烟方面,在种族和种族群体中观察到EOC危险因素关联的显著异质性.
- 在所有群体中,OC使用和OC平价都被发现与EOC风险的反向关联,在原住民夏威夷/太平洋岛民和亚洲女性中效果最强.
- 管结的保护性关联在夏威夷原住民/太平洋岛民参与者 (OR = 0.25) 与亚洲 (OR = 0.68) 和白人 (OR = 0.78) 参与者相比最为明显.
结论:
- 在EOC风险因素关联中存在种族和种族差异,可能受到不同的EOC基因型流行程度的影响.
- 为了完善EOC预防策略,研究群体的多样性至关重要.
- 研究结果强调,需要针对不同人群进行量身定制的卵巢癌预防方法.
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