基于高细胞兼容性多乳酸的电微纤维装有银纳米颗粒,在栗子上产生宁,具有针对性的抗菌活性和抗氧化作用
Rita Argenziano1,2, Sara Viggiano1, Antonio Laezza3
1Department of Chemical Sciences, University of Naples "Federico II", Naples 80126, Italy.
ACS applied materials & interfaces
|May 22, 2024
概括
研究人员开发了新的混合电纤维,将银纳米颗粒集成到栗子的木质素上,以增强组织再生. 这些材料具有强大的抗氧化和抗菌特性,提供针对性的感染保护,同时保持细胞兼容性.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
- 组织工程是组织工程.
背景情况:
- 电 (e-spun) 纤维对于组织再生中的细胞生长至关重要.
- 赋予这些纤维功能性质是一个活跃的研究领域.
- 银纳米粒子 (AgNP) 提供抗微生物和抗氧化剂的好处.
研究的目的:
- 用于制备混合电子织纤维与银纳米颗粒生成在栗子贝的木质素 (AgNP@CSL).
- 评估这些新型混合材料的抗氧化剂,细胞兼容性和抗菌性质.
- 通过平衡细胞保护和感染预防,评估它们在组织再生应用中的潜力.
主要方法:
- 混合纤维是使用d,l-多乳酸矩阵与素或纳米纤维素制造的,以提高水友性.
- 银(0) 纳米粒子 (AgNP) 通过无溶剂的机械化学降解AgNO3.0生成在栗子贝线素 (CSL) 上.
- 扫描电子显微镜 (SEM),传输电子显微镜 (TEM) 和各种化学试验用于表征和属性评估.
主要成果:
- SEM和TEM证实了e-spun纤维上存在AgNP@CSL (平均尺寸为30nm) 的存在.
- 含有AgNP@CSL的纤维显示出显著的抗氧化特性 (EC50 1.6 ± 0.1 mg/mL).
- 所有纤维类型都显示出与人类介质干细胞 (hMSCs) 的高细胞相容性.
- 纤维有效地抑制了大肠杆菌,白杆菌和假菌的生长.
- 共同培养实验显示,AgNP@CSL纤维保护了hMSCs免受大肠杆菌感染.
结论:
- 开发的AgNP@CSL加载的e-spun纤维为组织再生提供了一个有希望的生物材料.
- 这些混合材料有效平衡细胞兼容性和抗菌活性,提供有针对性的感染保护.
- 该研究强调了基于素的银纳米粒子复合材料在先进的生物医学应用中的潜力.
更多相关视频
12:21Fabrication and Characterization of Griffithsin-modified Fiber Scaffolds for Prevention of Sexually Transmitted Infections
Published on: October 31, 2017
7.5K
11:19Synthesis of Multi-walled Carbon Nanotubes Modified with Silver Nanoparticles and Evaluation of Their Antibacterial Activities and Cytotoxic Properties
Published on: May 10, 2018
10.2K
相关概念视频
Surface Membrane Barriers
The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
Bacterial Cell Wall
The bacterial cell wall is an essential structural component that encases the plasma membrane, preserving cellular integrity, determining shape, and protecting against osmotic stress. This rigid yet flexible structure primarily comprises peptidoglycan, a polymer that forms a mesh-like matrix conferring mechanical strength and flexibility.Peptidoglycan Composition and StructurePeptidoglycan, the core of the bacterial cell wall, comprises alternating units of N-acetylglucosamine (NAG) and...
Microbial Corrosion
Microbiologically Influenced Corrosion (MIC) is a significant form of material degradation caused by the metabolic activities of microorganisms. This phenomenon poses substantial challenges across various industries, including oil and gas, maritime, and water treatment sectors.MIC occurs when microorganisms, such as bacteria, archaea, and fungi, colonize metal surfaces, forming biofilms that alter the local electrochemical environment. These biofilms can lead to the production of corrosive...
Microbes in Food Production
Microbial fermentation is central to food biotechnology, enhancing flavor, texture, preservation, and stability. Fermentative microorganisms metabolize carbohydrates into organic acids, alcohols, and other metabolites that inhibit spoilage organisms and improve digestibility while contributing distinctive sensory qualities.In baking, amylases naturally present in flour hydrolyze starch into monosaccharides such as glucose, which Saccharomyces cerevisiae ferments anaerobically. Through...
Microbes in the Production of Fermented Foods
Lactic acid bacteria (LAB) and molds are instrumental in fermenting plant-based foods to enhance preservation and ensure year-round availability. These microbial processes convert plant carbohydrates into organic acids and other metabolites that inhibit spoilage organisms and contribute to the sensory qualities of the final product.In sauerkraut production, cabbage goes through a microbial succession that starts with cocci such as Leuconostoc mesenteroides. These microbes begin fermentation by...
iChip
The cultivation of environmental microorganisms has long been hindered by the inability to replicate complex native conditions in vitro. The isolation chip (iChip) addresses this limitation by facilitating the growth of previously uncultivable microorganisms through in situ incubation. Designed for high-throughput microbial cultivation, the iChip comprises hundreds of microchambers, each capable of housing a single microbial cell. These microchambers are loaded with a mixture of molten agar and...
