相关实验视频

Updated: Jun 25, 2025

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

圣炎与家族地中海热病中的炎症标志物之间的关系

Irfan Atik¹, Seda Atik²

¹Sivas Cumhuriyet University, Faculty of Medicine, Department of Radiology - Sivas, Turkey.

Revista da Associacao Medica Brasileira (1992)

|May 22, 2024

概括

在家族地中海热病患者中,神经炎患者的中性粒细胞数量,中性粒细胞/淋巴细胞比率和单细胞/淋巴细胞比率都较高. 这些血液炎症标志物可能有助于在FMF患者中诊断出神炎.

科学领域:

类风湿病学类风湿病学
免疫学免疫学免疫学
遗传学遗传学是一个

背景情况:

家庭地中海热 (FMF) 是最常见的单源性自身炎症性疾病.
圣炎,圣关节的炎症,可以是FMF患者的表现.
在FMF相关的圣炎中,血液炎症标记的诊断效用需要进一步研究.

研究的目的:

调查家族地中海热病患者中神经炎和血液炎症标志物之间的关联.
为了确定特定的炎症标志物是否可以预测FMF中的圣炎的存在.

主要方法:

分析了168名FMF患者的队列.
61名患有低背部/部疼痛的FMF患者接受了关节MRI.
根据MRI发现,患者被分为圣炎和非圣炎组.

主要成果:

在整体FMF队列中,圣炎的患病率为13.6%,在接受MRI的疼痛患者中为37.8%.
显著增加的中性粒细胞数量,中性粒细胞/淋巴细胞比率 (NLR),单细胞/淋巴细胞比率 (MLR) 和全身免疫炎症指数 (SII) 在圣炎组中观察到 (p<0.05).
ROC分析表明,NLR,MLR和SII是检测FMF患者神经炎的敏感标志物.

结论:

圣炎是家族地中海热病患者的一个值得注意的发现.
血液学炎症标记物,包括NLR,MLR和SII,显示出作为FMF中神经炎的诊断工具的希望.
这些标志物可能有助于早期识别和管理FMF相关的圣炎.

更多相关视频

Synovial Fluid Analysis to Identify Osteoarthritis

Synovial Fluid Analysis to Identify Osteoarthritis

Published on: October 20, 2022

Creation of a Knee Joint-on-a-Chip for Modeling Joint Diseases and Testing Drugs

Creation of a Knee Joint-on-a-Chip for Modeling Joint Diseases and Testing Drugs

Published on: January 27, 2023

相关概念视频

The JAK-STAT Signaling Pathway

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...

Inflammatory Bowel Disease II: Crohn's Disease

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...