移动边界以改善器官移植的可用性
1From the Renal Unit, Westmead Hospital, University of Sydney, Sydney, NSW, Australia.
概括
为了提高全球器官移植率,必须优化活体和死体器官捐献. 新的保存技术,如正常热 perfusion 可以提高器官的效用和解决短缺问题.
科学领域:
- 移植医学 移植医学
- 器官捐献科学 器官捐献科学
- 公共卫生政策 公共卫生政策
背景情况:
- 全球器官移植率仍然不足以满足患者的需求,阻碍了移植治疗的自主性.
- 优化活体和死体器官捐献对于增加移植能力至关重要.
- 目前的已故捐赠包括脑死亡和循环死亡的捐赠者.
研究的目的:
- 探索将全球器官移植率提高到每百万人口中100-120个器官的策略.
- 分析来自世界卫生组织全球捐赠和移植观察站的数据.
- 确定国家在加强器官捐献方面的挑战和机遇.
主要方法:
- 全球器官捐献和移植数据的审查.
- 对保存策略的分析,重点是正常热循环.
- 考虑实施先进的保存技术所面临的挑战.
主要成果:
- 优化生活和死者捐赠对于移植自给自足至关重要.
- 常温循环在预防缺血损伤和恢复边缘/老年捐赠器官功能方面表现有前途.
- 腹部器官的Normothermic in situ perfusion是有效的;胸部器官 perfusion需要进一步调查,并可能挑战死亡的法律定义.
结论:
- 各国必须加强所有类型的器官捐献者器官捐献能力.
- 在器官采集过程中进行的正常热输液为器官短缺提供了潜在的解决方案.
- 实施先进的保存技术可以提高器官的效用,实现移植自主.
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