肠道微生物群-胆酸轴调解了饮食中的类素和高尿血症之间的有益关联:一项前性研究
Lai-Bao Zhuo1, Yingdi Yang1, Congmei Xiao2,3
1Department of Epidemiology, Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. chenyum@mail.sysu.edu.cn.
Food & function
|May 22, 2024
概括
饮食中的干素可能会降低高尿路血症的风险. 这项研究表明,肠道微生物和胆汁酸调解了这种联系,为管理高尿酸水平提供了潜在的目标.
科学领域:
- 营养流行病学 营养流行病学
- 肠道微生物组研究研究
- 代谢学 代谢学 代谢学
背景情况:
- 在全球范围内,高尿路血症的患病率正在增加,这对公众健康构成了重大挑战.
- 饮食里格南摄入量与高尿素血症风险之间的关系尚不清楚.
- 了解这种关联对于制定预防策略至关重要.
研究的目的:
- 调查中国成年人饮食里格南摄入量与高尿素血症发病率之间的关联.
- 探索肠道微生物群和便代谢物在这种关系中的潜在调解作用.
主要方法:
- 这是一项涉及3801名中年和老年中国参与者的横截面和纵向研究.
- 通过食物频率调查问卷评估的饮食里格南摄入量.
- 肠道微生物群分析使用中枪元基因组测序;便代谢组通过UPLC-MS/MS确定.
主要成果:
- 较高的总类素摄入量,matairesinol,pinoresinol和secoisolariciresinol显示与高尿素血症发生率的反向关联.
- 在红素摄入组和超尿血症组之间观察到肠道微生物和便代谢资料的显著差异.
- 肠道微生物 (例如,死菌 (Fusobacterium mortiferum) 和蓝菌 (Blautia) 等) 的存在. 胆汁和胆汁酸 (例如,NorCA) 可能会调解保护作用.
结论:
- 饮食中的干素与患上高尿路血症的风险相反相关.
- 肠道微生物群-胆酸轴似乎是这种关联的关键调解者.
- 研究结果表明,对于管理与尿酸升高相关的疾病,有新的治疗点.
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