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Updated: Jun 25, 2025

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
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胎儿大脑对母亲炎症的反应需要微质细胞

Bridget Elaine LaMonica Ostrem1,2, Nuria Domínguez-Iturza1,3, Jeffrey A Stogsdill1,3

  • 1Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.

Development (Cambridge, England)
|May 22, 2024
PubMed
概括

怀孕期间的孕产妇免疫激活 (MIA) 改变胎儿的大脑发育. 微质细胞,大脑免疫细胞,对于调解后代这些长期的转录性变化至关重要,这表明它们是治疗点.

关键词:
皮层的发展 皮层的发展孕产妇的免疫激活微质细胞中的微质细胞神经炎症是一种神经炎症.

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相关概念视频

Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
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