心血管风险因素和大动脉狭窄:朝着初级预防的10年绝对风险图表
Emilie W Kjeldsen1, Jesper Q Thomassen1, Katrine L Rasmussen1,2,3
1Department of Clinical Biochemistry, Copenhagen University Hospital - Rigshospitalet, 2100 Copenhagen, Denmark.
European journal of preventive cardiology
|May 22, 2024
概括
诸如高血压和胆固醇等心血管风险因素与大动脉狭窄症 (AVS) 有关. 识别这些因素可以帮助创建通过改变生活方式来预防AVS的风险分数.
科学领域:
- 心脏病学 心脏病学
- 预防医学 预防医学
- 公共卫生 公共卫生
背景情况:
- 由于人口老龄化,大动脉狭窄 (AVS) 的发生率正在上升.
- 目前,对AVS仅存在外科手术,这凸显了预防策略的必要性.
- 识别可修改的风险因素对于早期预防AVS至关重要.
研究的目的:
- 调查心血管风险因素与AVS之间的关联.
- 开发初级AVS预防的10年绝对风险评分.
主要方法:
- 对93979名参与者的生活方式,生化数据和混因素的分析 (哥本哈根一般人口研究).
- 考克斯回归确定了AVS的显著风险因素.
- 细灰比例次危险模型创建了10年风险预测得分,考虑了竞争事件.
主要成果:
- 1,132名患者患有AVS.
- 相关的危险因素包括高残留胆固醇,甘油三,脂蛋白,缩血压,BMI,低遵守饮食指南,吸烟,高酒精摄入量,降脂疗法和糖尿病.
- 10年风险得分的关键因素:年龄,性别,BMI,静脉血压,脂蛋白和糖尿病.
- 绝对10年风险从<1%增加到19%.
结论:
- 心血管风险因素与AVS有关,这表明可能改变生活方式.
- 综合关键因素的风险图表可以识别有针对性的预防策略的高风险个人.
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