在人工眼治疗后,角膜上皮不规则的变化
Jacqueline Tan, Ngozi Chidi-Egboka1, Tianni Jia1
1School of Optometry and Vision Science, University of New South Wales (UNSW) Sydney, Sydney, New South Wales, Australia.
概括
干眼患者经历不规则的角膜表面,但滑性眼滴可以在48小时内使角膜光滑. 角膜上皮质厚度不规则的这种改善持续了4周,同时减少了眼部症状.
科学领域:
- 眼科医生 眼科 眼科
- 角质科学 角质科学
- 干眼疾病研究 干眼疾病研究
背景情况:
- 干眼病的特点是明显不规则的角膜上皮表面.
- 局部眼部滑剂通常用于管理干眼症状.
研究的目的:
- 为了比较两种滑性眼滴和盐水在减少角膜上皮质厚度不规则 (EIF) 和改善干眼患者的眼部症状方面的疗效.
- 为了评估EIF和症状在4周治疗期间的变化.
主要方法:
- 一项前性,随机化,调查员蒙面的研究,涉及48名中度至重度眼睛干燥的参与者.
- 参与者接受了0.15%的氨酸+基甲,0.2%的氨酸或盐水.
- 在基线和随访 (48小时,2周,4周) 测量角膜上皮厚度使用光学一致性断层扫描 (OCT).
- 眼部症状使用眼部表面疾病指数 (OSDI) 问卷进行评估.
主要成果:
- 与基线相比,所有随访点的水平EIF显著下降 (p=0.001),治疗方法之间没有显著差异.
- 随着时间的推移或治疗组之间没有观察到垂直EIF的显著变化.
- 眼部症状在治疗2周和4周后显著改善 (p<0.001),无论治疗类型如何.
结论:
- 局部眼部滑剂,包括盐水,有效地减少角膜上皮质厚度在48小时内沿水平午线不规则.
- 角膜表面规律的这些改善保持了长达4周的时间.
- 所有测试的治疗方法都显著缓解了与干眼疾病相关的眼部症状.
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