相关实验视频

Updated: Jun 25, 2025

Antigenic Liposomes for Generation of Disease-specific Antibodies

Antigenic Liposomes for Generation of Disease-specific Antibodies

Published on: October 25, 2018

提取物加剧小鼠的过敏免疫反应:对贝类过敏临床诊断的影响

Wai Sze Tong¹, Shanshan Li¹, Nicki Y H Leung²

¹School of Life Sciences, The Chinese University of Hong Kong, HKSAR, China.

Clinical reviews in allergy & immunology

|May 22, 2024

概括

与原始提取物或复合型菌素相比,煮熟的提取物显著增强了过敏敏感性和免疫反应. 这表明煮熟的提取物可能更有效地诊断贝类过敏.

科学领域:

免疫学免疫学免疫学
过敏学过敏学
食品科学食品科学食品科学

背景情况:

热菌素是主要的贝类过敏原,但还有其他过敏原.
了解过敏需要比较不同的敏感化方法.

研究的目的:

为了比较过敏免疫反应在小鼠敏感生,煮,或复合热胺素 (rTM).
在过敏个体中评估提取物和rTM的过敏性.

主要方法:

用生,煮熟的提取物或rTM对Balb/c小鼠进行敏感化和挑战.
系统性,细胞性和幽默性过敏反应的评估.
在过敏患者身上进行皮肤刺刺测试 (SPT) 和免疫血栓检测.

主要成果:

提取物和rTM都诱导了IgE和Th2反应与肠道炎症.
煮熟的提取物显示出最高的敏感率 (73.7%) 和最强的IgE/Th2反应.
热氨酸是主要的过敏原;热处理的热氨酸表现出更高的过敏性.
血素和糖原酸化酶被确定为小的过敏原.

结论:

煮熟的提取物增强了敏感性和Th2反应,表明热处理后过敏性增加.
该研究为进一步研究提供了三种过敏小鼠模型.
煮熟的提取物显示出对贝类过敏的更有效的临床诊断的潜力.

关键词:

食物过敏食物过敏鼠标模型模型过敏是因为过敏.皮肤刺刺测试试验托罗皮米奥辛 (Tropomyosin) 是一种可怕的药物.

更多相关视频

Measuring Local Anaphylaxis in Mice

Measuring Local Anaphylaxis in Mice

Published on: October 14, 2014

Assessment of Respiratory Function in Conscious Mice by Double-chamber Plethysmography

Assessment of Respiratory Function in Conscious Mice by Double-chamber Plethysmography

Published on: July 10, 2018

相关概念视频

Allergic Reactions

Allergic Reactions

Cross-reactivity

Cross-reactivity

Allergic Drug Reactions

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...