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逆转与代谢功能障碍相关的脂肪性肝病可以促进儿童心血管结构的健康:PROC研究
Menglong Li1, Wen Shu1, Yuchen Zou1
1Department of Child, Adolescent Health and Maternal Care, School of Public Health, Capital Medical University, Beijing, China.
The American journal of gastroenterology
|May 22, 2024
概括
在儿童中控制代谢功能障碍相关的脂肪性肝病 (MASLD) 与更好的心血管健康有关. 正常化了MASLD的孩子们表现出下降的动脉内心介质厚度和左心室质量.
科学领域:
- 儿科 儿科 儿科
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 越来越多地在儿童中被发现.
- 马斯尔德对儿科心血管发育的影响需要进一步研究.
研究的目的:
- 在儿科队列中调查MASLD和心血管结构发育之间的关联.
- 评估MASLD控制是否影响儿童的心血管结果.
主要方法:
- 一项纵向研究跟踪了北京的1356名儿童 (平均年龄6.6岁) 4.5年.
- 评估心血管结构的方法是使用动脉内心介质厚度和左心室质量.
- 监测了MASLD状态,将儿童分为持续性MASLD,事件MASLD和MASLD正常化组.
主要成果:
- 与持久性MASLD儿童相比,患有MASLD正常化的儿童表现出 significantly较低的动脉内膜介质厚度 (0.161比0.188毫米).
- 左心室质量在MASLD正常化 (4.5对12.4克) 的儿童中也明显低于持久性MASLD的儿童.
- 总共有59名儿童患有持续性MASLD,109人患有事件性MASLD,35人实现了MASLD正常化.
结论:
- 儿童中MASLD的控制和正常化与心血管结构发育的改善有关.
- 这些发现凸显了在儿童群体中管理MASLD的重要性,以减轻心血管风险.
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