神经内分泌瘤内的分类或命名的变化
Giulia Vocino Trucco1, Marco Volante2
1Pathology Unit, SS. Annunziata Hospital, Savigliano, Italy.
Endocrine-related cancer
|May 22, 2024
概括
世界卫生组织 (WHO) 的第五版分类标准化了神经内分泌瘤 (NEN) 的术语和诊断. 此更新引入了用于分类神经内分泌瘤 (NETs) 和神经内分泌癌症 (NECs) 的二进制系统,并改进了分级系统.
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
- 内分泌学 在内分泌学.
背景情况:
- 世界卫生组织 (WHO) 的神经内分泌瘤 (NEN) 分类需要更新,以确保统一的术语和诊断方案.
- 之前的版本建立了基础分类,但进步需要修订更广泛的解剖学覆盖和精细的分级.
- 第4版在非神经内分泌器官中引入了NEN,为进一步的整合和标准化奠定了基础.
研究的目的:
- 介绍世卫组织第五版神经内分泌瘤分类中的关键变化和进展.
- 强调采用二元分类系统 (神经内分泌瘤/癌瘤) 和修订分类策略.
- 强调新分类对多学科诊断,临床管理和未来研究方向的影响.
主要方法:
- 从世卫组织神经内分泌瘤分类第五版的更新指南的审查和综合.
- 分析针对差异化良好 (NETs) 和差异化不良 (NECs) 瘤的拟议二元分类系统.
- 检查基于线粒体指数,Ki-67和亡的修订分级系统,适应各种解剖位置.
主要成果:
- 介绍一个统一的术语和诊断方案的NENs跨不同的解剖位置.
- 实施二进制分类系统 (NETs与NECs) 和特定位置的分级标准.
- 认可肺部和胸腺NENs的癌类/NET术语,与胸部瘤分类保持一致.
结论:
- 世卫组织第五版分类促进了对NEN诊断和管理的标准化方法,促进了多学科的合作.
- 修订后的分类适应了特定地点的特征,同时确保了一致性,改善了对NEN行为的理解.
- 这一更新的框架支持将流行病学数据和分子分析整合到个性化治疗策略中.
相关概念视频
Cadherins in Tissue Organization
3.0K
The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
Cell sorting plays an...
Cell Sorting During Development
Cell sorting plays an...
3.0K
Metastasis
5.5K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.5K
Tumor Progression
6.3K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.3K


