帕洛斯米亚与问题饮酒有积极的关联,而幻象症与抑郁症状有积极的关联
Khushbu Agarwal1, Jeremy W Luk, Bethany L Stangl
1From the Section of Sensory Science and Metabolism, National Institute on Alcohol Abuse and Alcoholism, and National Institute of Nursing Research, National Institutes of Health, Bethesda, MD (KA, PVJ); Office of the Clinical Director, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD (JWL, MLS, DG, ND); Human Psychopharmacology Laboratory, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD (BLS, VAR); Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD (DG); Clinical NeuroImaging Research Core, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD (RM); Department of Neurology, Indiana University School of Medicine, Indianapolis, IN (DAK); and Section on Clinical Psychoneuroendocrinology and Neuropsychopharmacology, National Institute on Alcohol Abuse and Alcoholism, Division of Intramural Clinical and Biological Research and National Institute on Drug Abuse Intramural Research Program, National Institutes of Health (LL).
这项研究发现,像帕洛斯米亚这样的气味扭曲与更严重的酒精使用障碍 (AUD) 有关. 幻觉症,或嗅觉幻觉,与AUD患者抑郁症状增加相关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 公共卫生 公共卫生
背景情况:
- 酒精使用障碍 (AUD) 是一个主要的全球健康问题.
- 嗅觉功能障碍在长期饮酒的人群中被观察到.
- 嗅觉缺陷类型,抑郁症和问题饮酒之间的具体联系需要进一步研究.
研究的目的:
- 为了确定患有AUD的个体中嗅觉扭曲 (parosmia) 和幻觉 (phantosmia) 的患病率.
- 为了检查帕洛斯米亚,幻影症,问题饮酒和抑郁症状之间的联系.
主要方法:
- 250名患有AUD的参与者被调查了嗅觉功能,抑郁症状和问题饮酒.
- 关键措施包括酒精使用障碍识别测试 (AUDIT) 和患者健康问卷 (PHQ).
- 对年龄,性别,社会经济地位,种族,种族,COVID-19状态和吸烟状态进行统计分析.
主要成果:
- 5.2%的参与者报告了帕洛斯米亚和4.4%的参与者报告了幻影.
- 帕洛斯米亚明显与较高的AUDIT分数相关 (β = 7.14,P < 0.001).
- 幻影症与更高的PHQ得分有显著的关联 (β = 3.32,P = 0.03).
结论:
- 嗅觉缺陷,包括parosmia和phantosmia,与有问题的饮酒和AUD患者的抑郁症状密切相关.
- 这些发现强调了在临床环境中对AUD和抑郁症评估嗅觉障碍的重要性.
- 需要进一步的研究来探索这些关系并开发有针对性的治疗方法.
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