通过多功能纳米复合材料装载微针贴片增强感染糖尿病伤口愈合:诱导多个再生部位
Daojiang Yu1,2, Lei Chen2, Tao Yan2
1West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, 610041, China.
Advanced healthcare materials
|May 22, 2024
概括
一种新的微针 (MN) 贴片将Ag@MSN@CeO2纳米颗粒传递给感染的糖尿病伤口,通过减少炎症,抵抗细菌和增强组织再生来促进愈合.
科学领域:
- 再生医学是一种再生医学.
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
背景情况:
- 糖尿病伤口 (DWs) 由于组织修复受损和高感染率,在愈合过程中存在重大挑战.
- 传统疗法往往无法有效地穿透深层组织,从而限制了它们对复杂DWs的治疗效果.
- 先进的药物输送系统对于提高慢性伤口再生医学治疗结果至关重要.
研究的目的:
- 开发一种多功能微针 (MN) 贴片,用于增强药物输送到已感染的糖尿病伤口.
- 为创建核心外纳米颗粒 (Ag@MSN@CeO2) 具有抗菌,抗氧化和血管新生特性,用于伤口愈合.
- 评估MN平台在促进深层组织透和加速DW愈合方面的有效性.
主要方法:
- 制造一种含有Ag@MSN@CeO2纳米粒子的可溶性γ-PGA基微针贴片.
- Ag@MSN@CeO2纳米粒子的表征,详细说明它们的核心外结构和功能组件 (CeO2核心,MSN外,Ag兴奋剂).
- 在体外和体外评估MN贴片透深层组织的能力及其对感染的DW模型的治疗效果.
主要成果:
- 该MN贴片成功地穿透了深层组织,使得负载纳米粒子的有效输送成为可能.
- Ag@MSN@CeO2纳米粒子表现出抗菌活性,减少反应性氧物种,调节巨细胞反应,并促进血管再生和原沉积.
- 使用多功能MN贴片观察到感染糖尿病伤口的愈合过程显著加速.
结论:
- 开发的装有Ag@MSN@CeO2纳米颗粒的微针贴片是治疗感染糖尿病伤口的有希望的多功能系统.
- 这种创新方法克服了传统疗法的局限性,通过使深层组织药物输送,并解决伤口愈合的多个方面.
- MN@Ag@MSN@CeO2贴片在复杂的伤口感染的管理中具有很大的临床转化潜力.
相关概念视频
01:24Site-Targeted Drug Delivery Systems: Polymeric Carriers
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
01:31Diabetic Foot Ulcer
Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...
01:27Diabetic Retinopathy
DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
01:22Diabetic Neuropathy
DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...