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Updated: Jun 25, 2025

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上腺皮癌中的静脉血栓栓塞:一个回顾性分析
Marta Laganà1,2, Vania Balderrama-Brondani2, Kelsey Ruth Herrera3
1Medical Oncology Unit, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia at ASST Spedali Civili, Brescia, Italy.
The oncologist
|May 22, 2024
概括
静脉血栓栓塞 (VTE) 影响近19%的上腺皮质癌 (ACC) 患者,通常发生在晚期疾病. 虽然短期死亡率很高,但VTE在本研究中没有显著影响整体存活率.
科学领域:
- 在瘤学瘤学.
- 心脏病学 心脏病学
- 血液学 血液学 血液学
背景情况:
- 静脉血栓栓塞 (VTE) 是癌症患者死亡的重要原因.
- 在上腺皮癌 (ACC) 患者的VTE数据是有限的.
- 了解VTE患病率和ACC的影响对于患者护理至关重要.
研究的目的:
- 为了确定VTE在上腺皮癌 (ACC) 患者队列中的患病率.
- 评估VTE对ACC患者整体存活时间 (OS) 的影响.
- 在被诊断为ACC的患者中描述VTE事件.
主要方法:
- 对289名患有ACC的患者的数据进行了回顾性审查.
- 2010年2月至2022年6月期间从主要推中心收集的数据.
- 分析包括VTE患病率,类型,时间,严重程度以及与整体存活率的关联.
主要成果:
- 在ACC患者中,VTE的患病率为18.7% (54个事件).
- 肺栓塞 (PE) 和深静脉血栓塞 (DVT) 是常见的,有55.6%的人经历PE.
- 静脉瘤突发症经常发生于晚期ACC (3或4阶段),并与高短期死亡率相关,尽管对整体存活率没有统计学意义.
结论:
- 在患有ACC的患者中观察到高频率的VTE事件.
- 在ACC中,VTE通常发生在晚期疾病的背景下,并且与显著的短期死亡率有关.
- 需要进一步的研究来验证这些发现,并探索ACC中的VTE机制.
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