用S-citalopram打印的聚合物吸附剂的设计和合成:在选分离中的表征和应用
Hussam Y Alharbi1, Rua B Alnoman1, Majed S Aljohani1
1Chemistry Department, Faculty of Science, Taibah University, Yanbu, Saudi Arabia.
Journal of chromatography. A
|May 22, 2024
概括
开发了一种新型的S-citalopram选择性聚合物吸附剂,用于高效的药物分离. 这种印制聚合物表现出高吸附能力和有效的citalopram的反体分离.
科学领域:
- 聚合物化学 聚合物化学
- 分析化学 分析化学
- 制药科学 制药科学
背景情况:
- 药品的 chiral 分离对于药物的有效性和安全性至关重要.
- 开发选择性和高效的吸附剂材料仍然是分析化学的一个挑战.
研究的目的:
- 为了合成和描述一种新型的S-citalopram选择性聚合物吸附剂.
- 评估开发的材料的吸附能力和选择性特性.
- 为了证明吸附剂在分离奇塔洛普拉姆反体中的实用性.
主要方法:
- 悬浮聚合,以制造聚乙烯-化-双乙烯) 微粒.
- 通过乙二胺进行修改,并通过glyoxal进行后交叉链接.
- S-citalopram印记和提取以创建性腔.
- 使用13C NMR,FTIR,热重力测量分析,元素分析和SEM进行表征.
- 列色谱用于反聚合物分离.
主要成果:
- 成功合成了一种新的基于氨基酸的聚合物衍生物.
- 印制的聚合物在pH值8.8时具有高的S-citalopram吸附能力,为878mmol/g.
- 通过有效分离 (±) -citalopram反体,获得了97%的R-citalopram纯度和92%的S-citalopram纯度.
结论:
- 开发的S-citalopram印记聚合物是一种高效的吸附剂,用于选择性吸附和性分离.
- 这种材料为净化和分析citalopram enantiomers提供了一种有前途的方法.
- 该研究强调了分子印记技术在创建先进分离材料方面的潜力.
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