绿色空间暴露和血液DNA在出生和儿童时期的甲基化 - 一个多队列研究
Sofia Aguilar-Lacasaña1, Irene Fontes Marques2, Montserrat de Castro3
1ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública, Spain; Universitat de Barcelona, Barcelona, Spain.
Environment international
|May 22, 2024
概括
暴露于绿色空间可能会影响健康,但生物联系尚不清楚. 这项研究发现几乎没有证据表明绿色空间暴露会影响新生儿或儿童的DNA甲基化,尽管与特定基因的一些关联需要进一步研究.
科学领域:
- 环境表观遗传学环境表观遗传学
- 公共卫生 公共卫生
- 发展生物学 发展生物学
背景情况:
- 绿色空间暴露与改善健康结果有关,但生物学机制尚不清楚.
- 表观遗传修饰,如DNA甲基化,是环境健康影响的潜在媒介.
- 研究绿色空间对DNA甲基化的影响可以阐明促进健康的途径.
研究的目的:
- 为了检查住宅绿色空间暴露与带和儿童血液中的DNA甲基化模式之间的关联.
- 评估不同暴露窗口之间的关联:怀孕和累积暴露 (怀孕对儿童的评估).
主要方法:
- 利用了八个欧洲出生队列的数据 (2,988名新生儿,1849名儿童).
- 使用周围的绿色 (正常化差异植被指数) 和近距离指标评估绿色空间.
- 通过Illumina 450K/EPIC阵列测量DNA甲基化,使用强大的线性回归和元分析来识别DMP/DMR.
主要成果:
- 在假发现率<0.05.5的情况下,在绿色空间暴露和差异甲基化位置 (DMP) 之间没有发现显著的关联.
- 周围的绿色暴露与带和儿童血液中的四个差异甲基化区域 (DMR) 相反相关,与ADAMTS2,KCNQ1DN,SLC6A12和SDK1基因相关.
- 对细胞组成和空气污染进行调整的灵敏度分析没有实质性地改变研究结果.
结论:
- 这项研究发现了有限的证据,将绿色空间暴露与新生儿和儿童的血液DNA甲基化变化联系起来.
- 与四种DMR确定的关联需要进一步调查和复制.
- 了解绿色空间的表观遗传影响对于公共卫生干预至关重要.
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