从甲,甲和二甲基碳酸盐中合成的甲/伪和甲胺进行分析
Brendan M Miller1, James F Carter2, Sarah L Cresswell3
1Forensic Science Queensland, Coopers Plains, QLD 4108, Australia.
这项研究揭示,奇拉和稳定的同位素比率可以通过一种新的途径合成的乙丁,伪乙丁和甲基胺. 这种方法有助于确定这些物质的来源.
科学领域:
- 法医化学 法医化学
- 有机合成 有机合成
- 分析化学 分析化学
背景情况:
- 之前已经研究了一种新的合成途径,用于使用甲,甲和二甲基碳酸盐的以弗得林/伪以弗得林和甲基胺.
- 在此前的工作中,还为这种新型合成路径建立了杂质概况.
研究的目的:
- 通过新途径合成的以弗得林/伪以弗得林和甲基胺的奇拉和稳定同位素比率.
- 建立方法来区分由该途径产生的物质与其他来源的物质.
- 评估稳定同位素分析在确定这些化合物的合成来源方面的有用性.
主要方法:
- 合成的以弗得林/伪以弗得林和甲基胺的奇拉特征分析.
- 测量合成化合物的稳定同位素比 (δ13C和 δ2H).
- 从已知不同来源的物质中获得的资料和比率与已知不同来源的物质的资料和比率进行比较.
主要成果:
- 来自新途径的以弗得林/伪以弗得林和甲基胺表现出明显的性特征和稳定的同位素比率 (更负的 δ 13 C,平均值). -33.2‰;更积极的 δ2H).
- 这些独特的同位素特征允许区分"完全合成"",半合成"或"天然"的乙 / 伪乙和甲基胺.
- 通过这种途径产生的甲基胺显示出更积极的δ2H值,使其与从-2-中合成的甲基胺有所区别.
- 稳定同位素分析本身也有局限性,特别是对于特定的甲前体同位素值或与阿卡博里-莫莫塔尼反应产物区分时.
结论:
- 基拉和稳定同位素分析是识别通过新途径合成的乙 / 伪乙和甲基胺来源的有价值工具.
- 建议将稳定同位素分析和杂质分析结合起来,以全面确定物质的来源.
- 在特定场景中,可能需要进一步的研究来克服稳定同位素分析的局限性.
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