长期暴露于聚乙烯纳米颗粒会减少电网膜反应,并加剧因光线暴露引起的视网膜退化
Jincan He1, Shiyi Xiong2, Wenchuan Zhou1
1Department of Ophthalmology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092 China.
Journal of hazardous materials
|May 22, 2024
概括
长期暴露于聚乙烯纳米颗粒 (PS-NPs) 通过增加氧化应激和炎症来损害小鼠视网膜,可能导致视网膜退化并模仿与年龄相关的黄斑退化 (AMD) 的各个方面.
科学领域:
- 环境毒理学环境毒理学
- 眼睛毒理学 眼睛毒理学
- 纳米技术 纳米技术
背景情况:
- 塑料污染越来越令人担忧,纳米塑料 (NP) 对生物体构成潜在风险.
- 对于NP对视网膜的具体影响尚不清楚,需要进一步研究.
研究的目的:
- 为了研究聚乙烯纳米颗粒 (PS-NP) 暴露对小鼠视网膜的长期影响.
- 为了确定PS-NPs是否可以穿越血视网膜屏障并影响视网膜功能和细胞健康.
主要方法:
- C57BL/6J小鼠在饮用水中暴露于100nmPS-NP3个月.
- 使用电视网膜学评估视网膜功能,并在培养的光受体和视网膜色素上皮细胞 (RPE) 中研究细胞效应.
- 对暴露和受光挑战的小鼠的视网膜组织进行了转录组分析.
主要成果:
- 在视网膜组织中积累的PS-NP,增加氧化应激和活性氧物种 (ROS) 水平.
- 斯科托普电网膜反应减少,RPE细胞表现出受损的细胞活动和细胞结形成.
- 长期的PS-NPs暴露加剧了光诱导的光受体退化和视网膜炎症,与与年龄相关的黄斑退化 (AMD) 共享分子特征.
结论:
- 长期暴露于PS-NPs会通过氧化应激和炎症引起视网膜功能障碍.
- PS-NPs可以被认为是视网膜退化的环境风险因素.
- 这些发现表明,纳米塑料暴露与视网膜的AMD类病理变化之间存在联系.
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