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通过人类伪尿素合成酶TruB1识别pri-let-7的结构基础

Yumi Xuan1, Lei Wang1, Liang Zhang1

  • 1Department of Clinical Laboratory, The First Affiliated Hospital of USTC, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Ministry of Education Key Laboratory for Membraneless Organelles & Cellular Dynamics, Biomedical Sciences and Health Laboratory of Anhui Province, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, 230027, Hefei, PR China.

Biochemical and biophysical research communications
|May 22, 2024
PubMed
概括

人类伪尿素合成酶TruB1与pri-let-7a1结合,揭示了对let-7微RNA (miRNA) 成熟的结构性见解. 这种相互作用涉及特定的终端环结合和通过KRKK动机的静电相互作用,对于let-7生物发生至关重要.

关键词:
晶体结构 晶体结构模拟MD的模拟方法伪尤里丁合成酶的使用这就是TruB1的特点.让-7 让-7 让-7这是一个微型RNA.

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