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多种菌株益生菌无法调节喘表型,呼吸系统微生物群和猫的免疫反应
Julia D Remaks1,2,3, Aida I Vientos-Plotts1,2,4, Hansjorg Rindt1,4
1College of Veterinary Medicine, University of Missouri, Columbia, MO.
American journal of veterinary research
|May 22, 2024
概括
多种菌株益生菌没有改善喘症状或减少猫的呼吸道炎症. 该研究发现,使用益生菌时,微生物群落或免疫反应没有显著变化.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 免疫学 免疫学 免疫学
- 微生物组研究 微生物组研究
背景情况:
- 猫喘是一种常见的呼吸系统疾病.
- 抗炎性葡萄皮质类药物是标准的治疗方法.
- 益生菌在治疗猫喘中的作用尚不清楚.
研究的目的:
- 为了评估口服多种菌株益生菌在接受葡萄糖皮质醇治疗的喘猫的疗效.
- 评估益生菌对临床症状,呼吸道炎症和微生物群落的影响.
- 为了确定益生菌是否会改变猫喘中的免疫参数.
主要方法:
- 一个随机的,盲目的,安慰剂控制的试验,涉及13只喘猫.
- 猫接受了口服多菌株益生菌或安慰剂以及葡萄糖皮质类药物2周.
- 评估了业主感知到的改善,呼吸道异敏性,微生物群落 (16S rRNA测序) 和免疫标记 (PCR,ELISA).
主要成果:
- 在益生菌和安慰剂组之间,没有观察到所有者感知到的临床症状或呼吸道叶绿素友好症的显著差异.
- 益生菌没有改变支气管洗液,血液或口腔大中的微生物多样性 (α或β).
- 没有检测到关键免疫标记物 (细胞因子,转录因子,IgA) 的显著变化.
结论:
- 口服多种菌株益生菌没有减轻用葡萄糖皮质类药物治疗的猫的喘表型.
- 在这项研究中,益生菌未能改变呼吸道微生物群落或免疫反应.
- 未来的研究应该探索更长的治疗时间,不同的益生菌配方或替代的输送方法.
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