COVID-19疫苗接种和中风之间的关联:卡塔尔的一项全国性病例控制研究
Hiam Chemaitelly1, Naveed Akhtar2, Salman Al Jerdi3
1Infectious Disease Epidemiology Group, Weill Cornell Medicine-Qatar, Cornell University, Doha, Qatar; World Health Organization Collaborating Centre for Disease Epidemiology Analytics on HIV/AIDS, Sexually Transmitted Infections, and Viral Hepatitis, Weill Cornell Medicine-Qatar, Cornell University, Qatar Foundation - Education City, Doha, Qatar; Department of Population Health Sciences, Weill Cornell Medicine, Cornell University, New York, New York, USA.
这项研究发现,在卡塔尔接种COVID-19mRNA疫苗后,中风风险没有增加. 对3000多例中风病例和对照病例的分析表明,接种疫苗与不良事件无关.
科学领域:
- 流行病学 流行病学
- 疫苗学 疫苗学 疫苗学
- 神经学 神经学
背景情况:
- 冠状病毒疾病2019 (COVID-19) 流行病需要快速开发疫苗.
- 包括BNT162b2和mRNA-1273在内的mRNA疫苗被广泛用于COVID-19的预防.
- 了解COVID-19疫苗的长期安全性对于公共卫生至关重要.
研究的目的:
- 调查COVID-19 mRNA疫苗接种与中风风险之间的关联.
- 评估与不同疫苗接种计划 (单剂量,初级系列,强剂) 相关的中风风险.
- 检查不同类型的疫苗和不同人口群体之间的潜在关联.
主要方法:
- 在2020年12月至2023年4月期间,在卡塔尔进行了一项匹配的病例控制研究.
- 3036例急性中风病例与来自普通人口的3036例对照进行了匹配.
- 进行了统计分析,包括调整的赔率比率 (aOR) 和子组分析.
主要成果:
- 接种疫苗和中风的整体调整几率比为0.87 (95% CI:0.75-1.00),表明风险没有增加.
- 对于单剂量 (aOR 0.74),初级系列 (aOR 0.87),或强剂量 (aOR 0.91) 没有发现显著的关联.
- 对BNT162b2 (aOR 0.87) 和mRNA-1273 (aOR 0.86) 的分析显示,中风风险没有增加. 根据持续时间,人口统计和中风类型的亚组分析也没有显示出任何显著的关联,尽管对脑静脉鼻血栓形成的非显著趋势被注意到.
结论:
- 没有证据表明,在接种COVID-19mRNA疫苗后,中风风险增加.
- 这些发现适用于疫苗接种后的短期和长期,超过一年.
- 这项研究支持mRNA疫苗关于中风风险的安全性.
相关概念视频
Regulation of Stroke Volume
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
Cardiac Output II: Effect of Stroke Volume on Cardiac Output
Preload
Preload refers to the initial elongation of the cardiac myocytes before contraction and is related to the volume of blood filling the heart at the end of diastole, or end-diastolic volume. The...
Ischemic Heart Disease: Overview
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
Cardiac Output and Stroke Volume
In an average resting adult male, the typical cardiac...
Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
Vaccinations


