治疗缺血性中风通过改善血管结构和促进血管生成使用Taohong Siwu:一个整合性药理学策略
Linfeng Tang1, Dandan Wang2, Hao Chang1
1Department of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, China; Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei, 230012, China.
Journal of ethnopharmacology
|May 22, 2024
概括
陶洪西武 (THSWD) 能保护大脑血管,并在缺血性中风 (IS) 后促进新血管生长. 这项研究揭示了通过改善微血管代谢和功能来改善其机制.
科学领域:
- 综合性药理学 综合性药理学
- 神经科学是一个神经科学.
- 传统中国医学 (TCM) 是一种
背景情况:
- 新血管形成对于修复缺血组织至关重要.
- 陶洪西武 (THSWD) 在缺血性中风 (IS) 中显示出血管新生有前途.
- THSWD对IS新血管结构,功能和分子机制的确切影响需要进行研究.
研究的目的:
- 在缺血性中风模型中研究THSWD对新血管结构和功能的保护作用.
- 通过综合性药理学方法阐明THSWD治疗作用的基础分子机制.
主要方法:
- 评估了THSWD在中脑动脉封闭/再输 (MCAO/R) 的老鼠的影响,使用行为测试,TTC染色,HE染色,ELISA,LDF,埃文斯蓝色染色和免疫光.
- 雇佣了网络药理学,代谢学和实验验证,以发现分子机制.
- 评估了神经血管结构,功能和大脑微血管代谢障碍.
主要成果:
- THSWD显著降低了神经缺陷和心脏病发作量,缓解了BBB泄漏,改善了大脑血流.
- THSWD保留了新血管结构,刺激了血管生成,并改善了微血管代谢障碍 (脂酸,果糖/甘,纯素,乙烯脂代谢).
- THSWD显示出抗炎,抗氧化,能量代谢调节和抗血小板聚合效应.
结论:
- THSWD保护大脑血管结构和功能,并通过纠正MCAO/R大鼠的微血管代谢障碍来促进血管生成.
- 综合药理学为研究IS治疗中的TCM提供了一种强大的方法.
- THSWD为缺血性中风提供了多方面的治疗策略.
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