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开发和评估婴幼儿过敏反应的修改标准
Anna Handorf1, Ian R Roy1, Ari Cohen2
1Department of Pediatrics, Mass General for Children, Harvard Medical School, Boston, Mass; Tufts University School of Medicine, Boston, Mass.
概括
新的标准改善了婴儿和幼儿的过敏反应的识别. 修改后的临床指导方针更好地检测幼儿的过敏反应,解决了儿科紧急护理的未满足需求.
科学领域:
- 儿科过敏和免疫学
- 紧急医疗 紧急医疗
- 临床诊断 临床诊断 临床诊断
背景情况:
- 目前的过敏反应诊断标准在两岁以下的儿童中缺乏验证.
- 过敏反应在婴儿和幼儿中呈现的独特表现导致不足的识别.
- 对于改善儿科过敏反应的识别,存在着未得到满足的临床需求.
研究的目的:
- 为了确定年龄特定的迹象和症状,以准确诊断幼儿的过敏反应.
- 根据已建立的NIAID/FAAN指南,制定和评估修改过敏症标准.
- 为了提高婴儿和幼儿的过敏反应的识别.
主要方法:
- 对337个儿童急诊室因疑似过敏反应而遇到的病例进行了回顾性审查.
- 为"可能的过敏反应"制定修改后的临床标准.
- 修改标准与2006年NIAID/FAAN标准的比较分析.
主要成果:
- 该研究包括婴儿 (33%),幼儿 (39%) 和老年儿童 (29%).
- 修改后的标准确定了98%的病例,显著超过了NIAID/FAAN标准 (85%,P <.001).
- 在婴儿 (22.8%的增长,P<.001) 和幼儿 (10.3%的增长,P=.04) 的修改标准中,观察到更好的表现.
结论:
- 修改过敏症标准,包括婴儿特异性症状,提高了诊断准确度.
- 开发的标准显示,在婴儿和潜在的幼儿中,过敏反应的识别增加了.
- 建议在更大的队列中进一步验证.
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