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一个新的功能获取酸化部位调节PTPN22抑制TCR信号传递

Chuling Zhuang1, Shen Yang2, Carlos G Gonzalez3

  • 1Department of Medicine, Altman Clinical and Translational Research Institute, University of California, San Diego, California, USA.

The Journal of biological chemistry
|May 22, 2024
PubMed
概括

蛋白质氨酸酸酶非受体类型22 (PTPN22) 上的一个新型酸化位点增强了其T细胞受体 (TCR) 抑制活性. 这一发现为TCR信号调节和对自身免疫和癌症的潜在治疗策略提供了洞察力.

关键词:
在PTPN2222中使用.T细胞受体受体的 T 细胞受体.全osteric调节的调节.自体免疫性是一种自身免疫性.催化剂是一种催化剂.本质上是无序的区域.光蛋白质组学 光蛋白质组学 光蛋白质组学酸化的方法是:光化.转录组学 转录组学是指转录组学.氨酸酸酶是一种氨酸酸酶.

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